Pharmacological treatment for methamphetamine withdrawal: A systematic review and meta‐analysis of randomised controlled trials PMC

Studies in this review used a combination of objective measures and questionnaires assessing different aspects of sleep and due to these disparate outcomes and measures future pooled analysis of these data would be impossible. While there are not currently any FDA-approved medications to help with the methamphetamine withdrawal process, some prescriptions are given to help prevent short-term physical symptoms like tremors, nausea, and vomiting. Some prescriptions are also given to help with psychological and mood symptoms during recovery from addiction to crystal meth. Professional treatment for meth addiction involves inpatient or outpatient treatment.

It is also an opportunity for the person to ask questions about the facility and the care they provide. You can also try taking medication to help you sleep or manage uncomfortable symptoms. But your experience after consuming meth (or any other amphetamine, for that matter) can vary quite a bit. American Addiction Centers (AAC) is committed to delivering original, truthful, accurate, unbiased, and medically current information. We strive to create content that is clear, concise, and easy to understand.

  1. Those looking for a safe way to detox may enter into an extended inpatient rehab program if other methods have been tried and have failed, or a shorter-term detox program as a more cost-effective alternative.
  2. The same 2011 study found that participants slept a lot in the first few days of not using meth and reported higher post-sleep refreshment.
  3. After some time, a patient’s body will stabilize, and they can move on to the next stage of rehabilitation.
  4. Available statistical data indicates re-emergence of METH popularity and suggest an impending third epidemic of METH abuse.
  5. We publish material that is researched, cited, edited and reviewed by licensed medical professionals.

Depressive and psychotic symptoms accompany acute withdrawal from methamphetamine but resolve within 1 week. A study of MA-dependent participants, who initiated and maintained abstinence from the drug for up to 5 weeks, compared to a matched healthy comparison group. Research in primate models has found that methamphetamine alters brain structures involved in decision-making and impairs the ability to suppress habitual behaviors that have become useless or counterproductive.

Data extraction

Addiction specialists may instead use medication to provide relief of withdrawal symptoms from meth. Treatment may ease the mood symptoms and prevent short-term physical symptoms like tremors, nausea or vomiting. This assertion would be particularly valid for those subjects with significant depressive symptoms during this period of abstinence, as they are also likely to be experiencing high levels of craving for MA. It teaches its users skills that help to achieve abstinence from substance abuse and to increase retention to outpatient programs. This application is aimed to be used in conjunction with outpatient therapy and was shown to be effective in reducing METH use and craving during treatment [74].

If the home environment is a triggering space, particularly one in which meth was or is highly prevalent, it is not advisable to attempt detox at home. It is also not advisable to try home detox if you have a dual diagnosis or co-occurring mental condition. Methamphetamine withdrawal can be a dangerous process for some, but this is primarily due to dehydration. As long as the person stays hydrated and eats a balanced diet, they can combat this, especially with medical help.

Adverse Effects

AddictionResource aims to present the most accurate, trustworthy, and up-to-date medical content to our readers. Our team does their best for our readers to help them stay informed about vital healthcare decisions. When someone binges on methamphetamine, they go through two distinct phases. After a single dose, the comedown is similar to a hangover following a night of drinking alcohol at a bar. As you go through withdrawal from meth, your body will need time to adjust and heal. While the process can be challenging, understanding the different stages of withdrawal can help you feel more prepared.

However, our survey of depressive symptoms based upon the MAWQ did not reveal a significant decrease over 1–2 weeks of abstinence. The use of sleep as an outcome measure in clinical trials involving treatment for stimulant use is increasing. Reliable methods to objectively measure sleep outcomes should in future be harmonised across studies to allow for better synthesis of results.

These cravings can develop suddenly and may catch you off guard, making them difficult to manage. Knowing what to expect and how to manage these cravings will prepare you if a relapse does occur. Methamphetamine is a powerful and dangerous stimulant that can cause dependency after just one use. Withdrawal symptoms, including extreme cravings and feelings of depression, can be emotionally and physically intense and even lead to fatalities if not properly treated.

METH relapse remains the biggest problem in MUD and warrants more pre-clinical and clinical studies. The last Cochrane review of this topic [4], which employed a similar search strategy to ours, was conducted in 2008. In the 13 years following that report, our search found only five additional RCT, and only two of those were able to be meta‐analysed. This is in stark contrast to other withdrawal syndromes where, for example, a recent Cochrane review of a single pharmacotherapy (buprenorphine) for opioid withdrawal yielded 27 RCT of 3048 participants [63].

They foster a sense of belonging and shared experience that can be invaluable on the road to lasting sobriety. Knowing what you might face can help you feel more prepared and supported as you begin this journey. Remember, cbd addiction your body has a remarkable ability to heal, and with time and support, you’ll overcome this. Methamphetamine (meth) is a powerfully addictive stimulant drug, making the decision to quit an incredibly brave one.

2. History of Methamphetamine Use

Calls to our general hotline may be answered by private treatment providers. We may be paid a fee for marketing or advertising by organizations that can assist with treating people with substance use disorders. Because of the severity of the withdrawal symptoms one experiences when quitting meth, it is advised to go through the main part of the withdrawal stage under a medical professional’s supervision. Although, there is no specific FDA approved medications indicated for Meth detoxification, medications do exist to help ease physical and psychological withdrawal symptoms.

Meth Withdrawal Symptoms, Timeline and Detox Treatment

Over time, repetitive meth abuse can cause a person’s mind and body to deteriorate. Methamphetamine is one of the powerful stimulants of the central nervous system (CNS). It is sometimes used as a second-line treatment for attention deficit hyperactivity disorder and obesity; however, methamphetamine is better known as a recreational drug. Several partial hospitalization and intensive outpatient programs resnick neuropsychiatric hospital factors appear to predict CM treatment outcome, including problem severity, race, HIV status, education, and income [76]. For example, CM therapy was the least effective for participants who reported a long history of drug use [89] or more METH use during baseline [86], and it was the most effective in Caucasian participants [88, 89].

Some people may safely tolerate meth withdrawal without medical supervision or intervention. But others may opt for, or even require, supportive care to manage their symptoms. The same 2011 study found that participants slept a lot in the first few days of not using meth and reported higher post-sleep refreshment. Yet the overall quality of sleep, measured by the length of time it takes you to fall asleep and the number of times you wake up, remained low even after 3 weeks had passed.

Higher regular doses of meth affect the length of withdrawal in the same way. Meth works by increasing the amount of dopamine — the neurotransmitter that controls feelings of pleasure — in the brain. When the drug is removed, dopamine drops below natural levels, and the resulting loss of enjoyment is distressing. Use of this website and any information contained herein is governed by the Healthgrades User Agreement. The SAMHSA phone line can also help people who are caring for loved ones who have a substance use disorder.